Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels
Our results uncovered a novel mechanism of lymphatic contractile dysregulation mediated by the crosstalk between TRPV4-expressing myeloid cells, including LYVE1+ macrophages, and lymphatic muscle cells or lymphatic endothelial cells. These findings highlight potentially important roles of TRPV4 channels in lymphatic dysfunction associated with inflammation, including secondary lymphedema.
Authors
- Jinyeon Shin (ORCID: https://orcid.org/0000-0003-3570-7316)
- Min Li (ORCID: https://orcid.org/0009-0001-6648-375X)
- Victoria Akerstrom
- Charles E. Norton (ORCID: https://orcid.org/0000-0001-9442-4039)
- Michelle D. Lambert
- Scott D. Zawieja (ORCID: https://orcid.org/0000-0003-4658-3179)
- Timothy L. Domeier (ORCID: https://orcid.org/0000-0003-0340-6551)
- Rafael S. Czepielewski (ORCID: https://orcid.org/0000-0002-2475-3838)
- Jorge A. Castorena‐Gonzalez (ORCID: https://orcid.org/0000-0001-5252-375X)
- Raghu P. Kataru (ORCID: https://orcid.org/0000-0003-1315-7982)
- Kejing Song (ORCID: https://orcid.org/0000-0003-0976-5109)
- Stephen E. Braun (ORCID: https://orcid.org/0000-0002-4521-2678)
- Babak J. Mehrara (ORCID: https://orcid.org/0000-0001-5717-697X)
- Sarah E Broyhill (ORCID: https://orcid.org/0000-0003-2627-3368)
- Mary E. Schulz
- Tatia B. Goldberg
Institutions
- Oregon National Primate Research Center (US)
- Tulane University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Augusta University (US)
- Augusta University Health (US)
- National Cancer Center of Georgia (GE)
- University of Missouri (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/atvbaha.124.322100
- Citations
- 7
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.32