A multi-tissue and -breed catalogue of chromatin conformations and their implications in gene regulation in pigs
Our investigations have shed light on the pivotal roles of TADs in governing gene expression and even influencing traits. Our study has unveiled a holistic interplay between chromatin interactions and gene regulation across various tissues and pig breeds. Furthermore, we anticipate that incorporating markers, such as structural variants (SVs), and phenotypes will enhance our understanding of their intricate interactions.
Authors
- Lingzhao Fang (ORCID: https://orcid.org/0000-0003-1103-3679)
- Guoqiang Yi (ORCID: https://orcid.org/0000-0001-8248-9126)
- Hongwei Yin (ORCID: https://orcid.org/0000-0002-9373-5166)
- Qianyi Zhao (ORCID: https://orcid.org/0000-0002-4113-3155)
- Yang Liu (ORCID: https://orcid.org/0000-0002-3424-7111)
- Lijing Bai
- Wenye Yao
Institutions
- Agricultural Genomics Institute at Shenzhen (CN)
- Centre for BioSystems Genomics (NL)
- Chinese Academy of Agricultural Sciences (CN)
- Wageningen University & Research (NL)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s12864-025-11490-4
- Citations
- 2
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China