CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation
Establishment of a coculture system to dissect the molecular circuits between CD105<sup>+</sup> fibroblasts and macrophages that drive immunosuppressive macrophage polarization has broad utility in understanding mammary gland development and events that precede cancer initiation. CD105<sup>+</sup> fibroblasts and macrophages may coordinate to suppress immunosurveillance and increase breast cancer susceptibility.
Authors
- Mark A. LaBarge (ORCID: https://orcid.org/0000-0003-2405-4719)
- Jackson Gibson (ORCID: https://orcid.org/0000-0003-4204-3407)
- Yukiko Yamaguchi (ORCID: https://orcid.org/0009-0007-8461-5000)
- Eric G. Carlson (ORCID: https://orcid.org/0000-0002-2784-1729)
- Jennifer C. Lopez (ORCID: https://orcid.org/0000-0002-7544-1914)
- Saul J. Priceman (ORCID: https://orcid.org/0000-0002-8136-2112)
Institutions
- University of Southern California (US)
- City of Hope (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13058-025-02040-7
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- California Institute for Regenerative Medicine
- Hope Center for Neurological Disorders
- National Institutes of Health
- Center For Cancer And Aging