Serum anti-nucleocapsid antibody correlates of protection from SARS-CoV-2 re-infection regardless of symptoms or immune history
These observations highlight the potential of anti-N antibody level as a correlate of protection against SARS-CoV-2 asymptomatic infection and re-infection. The findings indicate that individuals with hybrid immunity have a distinct protective immunity against both symptomatic and asymptomatic infection beyond serum anti-S and neutralizing antibodies against circulating viral strains, which correlate with serum anti-N antibodies.
Authors
- Daisuke Yoneoka (ORCID: https://orcid.org/0000-0002-3525-5092)
- Hiromizu Takahashi (ORCID: https://orcid.org/0000-0002-5055-7937)
- Takaji Wakita (ORCID: https://orcid.org/0000-0002-3701-2940)
- Takayuki Kanno (ORCID: https://orcid.org/0000-0002-5151-3012)
- Ryuhei Sakamoto
- Motoi Suzuki (ORCID: https://orcid.org/0000-0002-8340-0880)
- Tadaki Suzuki (ORCID: https://orcid.org/0000-0002-3820-9542)
- Akira Ainai
- M. Hayakawa (ORCID: https://orcid.org/0000-0002-9498-4711)
- Takeshi Arashiro (ORCID: https://orcid.org/0000-0002-5215-1500)
- Shô Miyamoto (ORCID: https://orcid.org/0000-0001-6541-1722)
- Hiromi Hibino
- Ryo Kinoshita (ORCID: https://orcid.org/0000-0002-0116-4598)
- Satoru Arai
- Akiko Sataka
- Koki Numakura
Institutions
- Chiba University (JP)
- Juntendo University (JP)
- National Institute of Infectious Diseases (JP)
- National Center for Global Health and Medicine (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1038/s43856-025-00894-8
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science
- Precursory Research for Embryonic Science and Technology