Bifunctional Ionic Liquids Induced Electrochemical C–H Arylation of Quinoxalin(on)es with Aryltriazenes
An efficient bifunctional ionic-liquid-induced electrochemical C-H arylation of quinoxalin(on)es with aryltriazenes has been developed. The reaction utilizes aryltriazenes as stable arylation reagents and ionic liquids as promoter and electrolyte. Various arylated quinoxalin-2(1<i>H</i>)-ones, quinoxaline and 2-methyldibenzo[<i>f,h</i>]quinoxaline were assembled in modest to excellent yields under mild, metal- and oxidant-free conditions. The developed protocol features simple operation, good functional group tolerance, good selectivity, product derivatization, and practical gram-scale synthesis in batch and continuous-flow processes.
Authors
- Weiwei Jin (ORCID: https://orcid.org/0000-0002-5996-3229)
- Chenjiang Liu (ORCID: https://orcid.org/0000-0002-8241-0809)
- Ziren Chen (ORCID: https://orcid.org/0000-0002-3298-9584)
- Chen–Yu Li (ORCID: https://orcid.org/0000-0002-0336-9888)
- Bin Wang (ORCID: https://orcid.org/0000-0002-8755-6401)
- Yonghong Zhang (ORCID: https://orcid.org/0000-0002-7740-9408)
- Yu Xia (ORCID: https://orcid.org/0000-0002-0591-9169)
- Wei Xu
- Shaofeng Wu (ORCID: https://orcid.org/0009-0008-8396-1742)
Institutions
- Xinjiang University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1021/acs.joc.5c00460
- Citations
- 8
- Primary Topic
- Ionic liquids properties and applications
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Science and Technology Commission of Shanghai Municipality
- International Science and Technology Cooperation Programme