Genomic changes of Lassa virus associated with mammalian host adaptation
During adaptation to guinea pigs, no significant new mutations occurred. Instead, a selection pressure on two genes of the L segment was observed resulting in their increased frequency in the genome population during passaging.
Authors
- Catherine Hartley (ORCID: https://orcid.org/0000-0001-9014-1015)
- Susan Fotheringham (ORCID: https://orcid.org/0000-0001-5440-8747)
- Lucy Crossley
- Neil Almond (ORCID: https://orcid.org/0000-0001-6105-0616)
- Victoria Graham (ORCID: https://orcid.org/0000-0002-3421-6243)
- Emma Kennedy (ORCID: https://orcid.org/0000-0002-3632-6163)
- Julian A. Hiscox (ORCID: https://orcid.org/0000-0002-6582-0275)
- Xiaofeng Dong (ORCID: https://orcid.org/0000-0003-1438-4079)
- Sarah Kempster (ORCID: https://orcid.org/0000-0002-4309-1489)
- Roger Hewson (ORCID: https://orcid.org/0000-0003-2273-3152)
- Stuart Dowall (ORCID: https://orcid.org/0000-0001-7378-8167)
- Linda Easterbrook
- Stephen Findlay‐Wilson (ORCID: https://orcid.org/0000-0002-6805-2574)
- Tessa Prince (ORCID: https://orcid.org/0000-0002-8796-2629)
- Jack Smith
Institutions
- Defence Science and Technology Laboratory (GB)
- University of Liverpool (GB)
- National Institute for Biological Standards and Control (GB)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s12864-025-11666-y
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Health and Social Care
- Innovate UK