Systemic Changes in Adults With a Fontan Circulation: Insights From the Plasma Proteome
This study represents a small step in understanding the pathophysiological consequences of the Fontan circulation. Based on biological pathways and proteins displaying changes, we speculate local hypoxia to be a potential driver for multiple of the reported changes. This study provides the foundation and direction for future studies wanting to examine changes in detail or explore possible therapeutic targets.
Authors
- Niklas Telinius (ORCID: https://orcid.org/0000-0002-8327-6461)
- Tue Bjerg Bennike (ORCID: https://orcid.org/0000-0003-4354-1731)
- Maren Ravndal (ORCID: https://orcid.org/0000-0001-8174-9811)
- Benjamin Kelly (ORCID: https://orcid.org/0000-0001-7472-4237)
- Vibeke E. Hjortdal (ORCID: https://orcid.org/0000-0002-8047-0015)
- Peter Bach
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/jaha.124.038648
- Citations
- 7
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.48