Age‐Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All‐Cause Mortality in a Sardinian Population Cohort
Because of its consistent ability to predict functional and clinical outcomes, including all-cause mortality, we conclude that GDF-15 serum levels serve as a robust biomarker for the continuum from health to the emergence of clinical disease during aging and, subsequently, to the likelihood of mortality.
Authors
- Jun Ding (ORCID: https://orcid.org/0000-0002-4302-5027)
- Carlo Sidore (ORCID: https://orcid.org/0000-0001-7504-7477)
- Maria Grazia Piras (ORCID: https://orcid.org/0000-0001-9004-0900)
- Antonella Mulas (ORCID: https://orcid.org/0000-0002-6856-1483)
- Marco Orrù (ORCID: https://orcid.org/0000-0003-2730-4517)
- Michele Marongiu (ORCID: https://orcid.org/0000-0002-7289-9815)
- Francesco Cucca (ORCID: https://orcid.org/0000-0002-7414-1995)
- Myriam Gorospe (ORCID: https://orcid.org/0000-0001-5439-3434)
- Alessandro Delitala (ORCID: https://orcid.org/0000-0003-1729-8969)
- Angelo Scuteri (ORCID: https://orcid.org/0000-0003-4784-5441)
- Edward G. Lakatta (ORCID: https://orcid.org/0000-0002-4772-0035)
- Valeria Orrù (ORCID: https://orcid.org/0000-0002-6047-4625)
- Christopher H. Morrell (ORCID: https://orcid.org/0000-0001-5080-7142)
- Sandra Lai (ORCID: https://orcid.org/0000-0003-4198-9989)
- Richard Oppong (ORCID: https://orcid.org/0000-0002-3244-6694)
- Edoardo Fiorillo (ORCID: https://orcid.org/0000-0002-8690-4988)
- Yong Qian (ORCID: https://orcid.org/0000-0002-6937-2449)
- David Schlessinger (ORCID: https://orcid.org/0000-0001-9638-961X)
Institutions
- University of Sassari (IT)
- Azienda Ospedaliero-Universitaria Cagliari (IT)
- Consorzio Roma Ricerche (IT)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/jaha.124.036253
- Citations
- 4
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.67