Gastroprotective effect of Etawa goat's milk through biochemical biomarkers

The prevalence of gastritis in Indonesia in 2020 reached 40.8%. Previous research proved goat milk to be anti-inflammatory in rat models of colitis. Goat milk feeding contributed to intestinal repair and protection with reduced colonic lesion scores in colonic tissue compared to control rats. This study aimed to investigate the gastroprotective effects of Etawa goat's milk in ethanol-induced gastric damage in vivo. In this study, 25 male Sprague-Dawley rats (SD) were divided into 5 groups; normal control group (NOR), ethanol group (EtOH), and three goat milk (GM) groups (given 0.5, 1 mL and 1.5 mL/200 g BW for 30 days intragastrically). After administration of GM for 30 days, all groups except for the normal control group had acute gastroduodenal damage after three days of intragastrical administration of 80% ethanol (5 mL/kg). Myeloperoxidase (MPO), superoxide dismutase (SOD), and histamine biomarkers in plasma were measured. Pretreatment with goat milk significantly protected rats from ethanol-induced gastric damage which aids in the reduction of the MPO and histamine activity and increase SOD activity.