Gross Morphological Changes in Cisplatin Induced Nephrotoxicity among the Wister Albino Rats

Background: Cisplatin is always used alongside other chemotherapy drugs in management of neoplastic conditions. Despite its clinical effectiveness, it has been associated with acute kidney disease to the patients that uses it. However, there is paucity of data on gross morphological changes on the kidneys following cisplatin induced nephrotoxicity. Objectives: The study aimed at assessing the gross morphological changes in cisplatin induced nephrotoxicity. Methodology: The study employed a posttest control experimental study design. Ten animals were randomly separated into two groups of control and experimental groups of five animals each. The control group was only fed and never administered with any drug. The experimental group was administered with stat dose of 0.28mg/kg/bwt/ intraperitoneal cisplatin. On the sixth day all animals were sacrificed. Results: The study found out that there were significant changes in gross morphology in terms of mean weight, width, volume, thickness and length of the rat’s kidney following cisplatin induced nephrotoxicity. Conclusion: A stat dose of 0.28mg/kg/bwt intraperitoneal cisplatin can cause gross morphological changes in kidneys.