The competing endogenous <scp>RNA</scp><i>lnc94641</i>–<scp>miR957</scp>‐3p mediates male fertility in <scp><i>Zeugodacus cucurbitae</i></scp> Coquillett
These results revealed a ceRNA axis mediated by 'lnc94641-miR957-3p-VGKC5/OR85c' involved in spermatogenesis that impairs male fertility in the melon fly. Molecular perturbations (lncRNA knockdown or miRNA overexpression) consistently impair sperm production and offspring viability by dysregulating ion channels and chemosensory genes. This mechanistically resolved pathway, centered on the core components VGKC5 and OR85c, revealed conserved reproductive vulnerabilities that could enable the targeted genetic control of this agricultural pest. © 2025 Society of Chemical Industry.
Authors
- Guy J. Smagghe (ORCID: https://orcid.org/0000-0001-8334-3313)
- Ying Yan (ORCID: https://orcid.org/0000-0002-1247-3302)
- Dong Chen (ORCID: https://orcid.org/0000-0003-2018-1120)
- Weijun Li (ORCID: https://orcid.org/0000-0003-4887-4260)
- Qingwei Zhang (ORCID: https://orcid.org/0000-0001-6302-2424)
- Dong Wei (ORCID: https://orcid.org/0000-0002-3625-4358)
- Jin‐Jun Wang (ORCID: https://orcid.org/0000-0002-8777-5268)
- Hong‐Bo Jiang (ORCID: https://orcid.org/0000-0002-7314-7391)
- Hongliang Han
Institutions
- Southwest University (CN)
- Justus-Liebig-Universität Gießen (DE)
- Ghent University (BE)
- Jiangxi Agricultural University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1002/ps.8874
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Higher Education Discipline Innovation Project
- National Key Research and Development Program of China