The whole genome analysis of the wild-type and attenuated orf virus reveals that ORF022 facilitates viral replication
Our findings suggest that the ORF022 in ORFV wild-type strain inhibits the host inflammatory response, reduces the immune response to ORFV, and facilitates viral replication. SNP events in attenuated strains (aFX0910) are one of the reasons for its attenuation. Investigations into the genomic sequences of attenuated viruses and the functional impact of mutated genes provide valuable insights into the mechanisms underlying ORFV attenuation and offer a foundation for the development of more effective ORFV vaccines.
Authors
- Zhannur Niyazbekova (ORCID: https://orcid.org/0000-0002-8556-0212)
- Youquan Bu (ORCID: https://orcid.org/0000-0002-0833-0640)
- Dekun Chen (ORCID: https://orcid.org/0000-0002-3215-9337)
- Suhua Feng (ORCID: https://orcid.org/0000-0001-6048-0083)
- Wentao Ma (ORCID: https://orcid.org/0000-0002-4747-1489)
- Xi Chen (ORCID: https://orcid.org/0000-0001-5947-3046)
- Wenbo Liu (ORCID: https://orcid.org/0000-0003-2560-0777)
- Tian Jing (ORCID: https://orcid.org/0000-0002-5634-9725)
- Xiaolong Gao
- Yunpeng Wang
Institutions
- Northwest A&F University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s12864-025-11663-1
- Citations
- 2
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 2.07