Three approaches to determining clinically meaningful benefit on the Cohen‐Mansfield Agitation Inventory in dementia clinical trials for agitation
For the CMAI total score, the MCID was -4 points over shorter time scales and -11 points for longer time scales.Worse agitation severity was associated with higher MCID estimates.There was high expert consensus that a noticeable treatment benefit was not worthwhile if it occurred after 12 weeks or had no impact on caregiver/staff distress/time resources.
Authors
- Chineze Ivenso (ORCID: https://orcid.org/0009-0003-3690-2698)
- Rebecca J. Howard (ORCID: https://orcid.org/0000-0003-2049-3378)
- Sube Banerjee (ORCID: https://orcid.org/0000-0002-8083-7649)
- Penny Rapaport (ORCID: https://orcid.org/0000-0003-0479-6950)
- Maria I. Lapid (ORCID: https://orcid.org/0000-0002-1163-5584)
- Suzanne Reeves (ORCID: https://orcid.org/0000-0001-8053-7024)
- Lon S. Schneider (ORCID: https://orcid.org/0000-0002-4636-6150)
- Kathy Y Liu (ORCID: https://orcid.org/0000-0002-7482-2758)
Institutions
- University of Southern California (US)
- Mayo Clinic (US)
- University of Nottingham (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Aneurin Bevan University Health Board (GB)
- Maudsley Hospital (GB)
- St Cadoc's Hospital (GB)
- Queen's Medical Centre (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70099
- Citations
- 2
- Primary Topic
- Psychiatric care and mental health services
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Yale University
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Ministerul Cercetării, Inovării şi Digitalizării
- National Institute for Health and Care Research
- University College London
- Medical Research Council