Identification and Validation of Th1-Selective Epitopes Derived from Proteins Overexpressed in Breast Cancer Stem Cells
CSC/EMT-associated antigens are immunogenic in humans and can be targeted using Th1-selective epitope-based vaccines. Immunization with these epitopes effectively inhibits tumor growth in multiple murine models of breast cancer. These findings support further clinical evaluation of CSC/EMT-targeted vaccines, especially for high-risk or advanced-stage breast cancer patients.
Authors
- Meredith Slota (ORCID: https://orcid.org/0000-0001-8492-6705)
- Daniel R. Herendeen
- Mary L. Disis (ORCID: https://orcid.org/0000-0001-7653-4648)
- Denise L. Cecil (ORCID: https://orcid.org/0000-0002-9923-3618)
- Megan M. O’Meara
- Yushe Dang (ORCID: https://orcid.org/0000-0002-7661-0855)
- Lauren R. Corulli
Institutions
- University of Washington (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3390/vaccines13050525
- Citations
- 2
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- U.S. Department of Defense