Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism
Overall, our results demonstrated that Fuzi could regulate gut microbiota and microbial bile acid metabolism, the microbial metabolite THDCA acts on TGR5-cAMP-PKA signaling pathway and NLRP3 inflammasome to reduce cold-related arthritis. Our study suggests that supplementation of Fuzi or THDCA can be of great value for the prevention and clinical treatment of cold-related RA.
Authors
- Jinlu Wu (ORCID: https://orcid.org/0000-0003-3059-9168)
- Wuwen Feng (ORCID: https://orcid.org/0000-0001-7850-5357)
- Yaochuan Zhou
- Dandan Zhang (ORCID: https://orcid.org/0000-0001-7649-7605)
- Juan Liu (ORCID: https://orcid.org/0000-0002-8693-4271)
- Cheng Peng (ORCID: https://orcid.org/0000-0002-7406-8599)
Institutions
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13020-025-01123-z
- Citations
- 4
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan Provincial Administration of Traditional Chinese Medicine