Short Tandem Repeat (STR) Somatic Mutation in Non-Melanoma Skin Cancer (NMSC): Association with Transcriptomic Profile and Potential Implications for Therapy
Our findings suggest that this STR somatic mutation status might potentially be used to select BCC patients who could benefit from certain precision therapy including hedgehog inhibitors, gamma-secretase inhibitors, anti-Vasuclar endothelial growth factor (<i>VEGF</i>), proteasome inhibitors, and immune check-point inhibitors.
Authors
- Habibul Ahsan (ORCID: https://orcid.org/0000-0001-9808-377X)
- Christopher R. Shea (ORCID: https://orcid.org/0000-0002-3780-8113)
- Maria Argos (ORCID: https://orcid.org/0000-0003-4234-252X)
- Farzana Jasmine (ORCID: https://orcid.org/0000-0002-5980-1174)
- Muhammad G. Kibriya (ORCID: https://orcid.org/0000-0001-9784-6958)
- Md. Tariqul Islam (ORCID: https://orcid.org/0000-0003-4056-8760)
- Armando Almazan
Institutions
- Boston University (US)
- Chicago Department of Public Health (US)
- University of Chicago (US)
- University of Chicago Research Bangladesh (BD)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3390/cancers17101669
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Chicago
- National Institutes of Health
- University of Chicago Medicine