A comprehensive evaluation and meta-analysis of the efficacy of autologous conditioned serum vs platelet-rich plasma in knee osteoarthritis treatment

The results obtained indicate that some patients with knee OA can obtain sustained relief from pain and improve function more than one year after treatment with anti-inflammatory ACS. Sustained pain relief and functional recovery are also likely due to regulatory mechanisms on inflammation and homeostasis of the joint. This meta-analysis indicates that ACS is more effective than PRP in relieving pain and improving joint function in knee OA. Further studies should be directed towards standardization of protocols, determining the cost, and looking at other outcomes over longer periods to better understand the benefits and refine the clinical use.