The Daily and Two-Day Usage of Low-Dose Atropine on Myopic Control in a Low-Myopia Population

<b>Objectives</b>: The aim of this study was to evaluate the effectiveness of using low-dose atropine (ATR) at different instillation frequencies on myopia control in a low-myopia population. <b>Methods</b>: A retrospective cohort study was conducted, and patients using 0.01% ATR and exhibiting a myopia degree ranging from +0.00 to -1.00 diopter (D) were included. A total of 32 and 26 eyes from 32 and 26 individuals were included in the daily group and two-day group, respectively. The main outcomes of this study are the progression of the spherical equivalent refraction (SER) and the elongation of the axial length (AXL). The Mann-Whitney U test and generalized linear model were used to perform the statistical analysis. <b>Results</b>: After a follow-up period of one year, the change in SER was similar between the daily group and two-day group (-0.24 ± 0.09 versus -0.26 ± 0.08, <i>p</i> = 0.393). In addition, there was an insignificant difference in AXL elongation between the daily group and two-day group (0.09 ± 0.07 versus 0.10 ± 0.09, <i>p</i> = 0.655). The trends observed in SER progression (<i>p</i> = 0.604) and AXL elongation (<i>p</i> = 0.779) were statistically identical between the daily group and the two-day group. <b>Conclusions</b>: The results of the two-day use of low-dose ATR regarding SER and AXL control are similar to those with the daily use of low-dose ATR in children with low myopia.