KLRG1 expression induces functional exhaustion of NK cells in colorectal cancer patients
The present study demonstrates that NK cells in CRC patients exhibit functional exhaustion, and KLRG1 blockade restores the effector function of NK cells, indicating that targeting KLRG1 represents a promising strategy for immunotherapy in patients with CRC.
Authors
- Kangli Cao (ORCID: https://orcid.org/0009-0000-3486-9837)
- Cairui Xu (ORCID: https://orcid.org/0009-0002-4126-1701)
- Meijuan Zheng (ORCID: https://orcid.org/0000-0002-7378-3355)
- Ling Tang (ORCID: https://orcid.org/0000-0002-2793-7843)
- Along Ma (ORCID: https://orcid.org/0009-0001-5409-460X)
- Yuanhong Xu
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s00262-025-04059-3
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China
- Anhui Medical University