SP1 promotes triple-negative breast cancer progression by targeting USP5
Our research findings indicate that the SP1-USP5 signaling pathway is significantly involved in the advancement of TNBC, and periplocin's ability to target USP5 presents a potential therapeutic approach for managing TNBC. These results offer valuable insights for the development of novel treatment strategies for TNBC patients.
Authors
- Jie Xiong (ORCID: https://orcid.org/0000-0002-7547-5049)
- Fu-Sheng Deng
- Xiaojian Han (ORCID: https://orcid.org/0000-0003-0477-7522)
- Zi-Mei Peng
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-9257-1449)
- Shuo Wu (ORCID: https://orcid.org/0000-0003-3684-4363)
- Pengfei Luo (ORCID: https://orcid.org/0000-0002-3358-1070)
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s12935-025-03802-1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province