Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)

The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This uncertainty raises the question of whether LP presents different morbidity and mortality profiles depending on the neoplasm type, potentially aiding decision-making. To compare postoperative outcomes by tumor type in a prospective series of LPs in Spain. The SPANDISPAN Project is a prospective, multicenter, observational study conducted in hepato-pancreato-biliary units from February 2022 to January 2023. A total of 311 patients from 41 Spanish centers participated. Patients were categorized by etiology: Adenocarcinoma (ADC), Intraductal Papillary Mucinous + Mucinous Cystic Neoplasms (IPMN + MCN), Neuroendocrine Tumors (NET), and Others. Pancreatic surgery-specific complications were defined by the International Study Group on Pancreatic Surgery (ISGPS). Postoperative complications were similar overall and for Clavien-Dindo grade > II. No significant differences were observed in POPF, except that grade B/C was more frequent in NET (29.6 %, p < 0.039), mainly due to grade B (53.3 %). No differences were found in PPH or DGE, though the severity of hemorrhage differed significantly (p < 0.035), with grade B more common in Others and grade C in NET (66.7 %). No significant differences in complication rates were found based on etiology. Non-functioning NETs in elderly patients should be carefully assessed due to the increased severity of POPF, PPH, and reoperation rates.

Authors

Institutions

Publication Details

Journal
Asian Journal of Surgery
Published
2025-05-15
DOI
https://doi.org/10.1016/j.asjsur.2025.04.182
Citations
1
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
1.05

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)

Francisco J. Alcalá, Mario Serradilla‐Martín, Javier Mínguez, A Vélez Blanco et al.
1 citations
Asian Journal of Surgery
Pancreatic and Hepatic Oncology Research
1.05
article

Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)

Francisco J. Alcalá, Mario Serradilla‐Martín, Javier Mínguez, A Vélez Blanco, Fernando Rotellar, Belinda Sánchez Pérez, Enrique Asensio, Elsa Marques, Marina Garcés‐Albir, Alberto Miyar, Isabel Jaén-Torrejimeno, Natalia Zambudio, María Jesús Pena Castro, Miguel Ángel Gómez‐Bravo, Carmen González‐Lois, Miguel Manzanares, G. Suárez, Juan Luís Blas, Belén Hernández, Pablo Martí‐Cruchaga, Manuel Nogueira-Sixto, Carmen Payá, Betsabé Reyes, Carlos Domingo del Pozo, Santiago López‐Ben, Luis Muñoz‐Bellvís, Inmaculada Lasa, Carmelo Loinaz, Enrique Toledo, Gabriel García, Pilar Elena González, Santiago Sánchez-Cabús, C. Alcázar, Daniel Aparicio-López, Fernando Burdı́o, Alfredo Escartín, Alicia Calero, M. Rodríguez-López, Antonio Calvo, Jorge Roldán de la Rúa, José Ignacio Miota, Juan Jesús Rubio-García, Benedetto Ielpo, Juli Busquets, Gerardo Blanco‐Fernández, Sergio Estévez-Fernández, Jorge Calvo, Mar Achalandabaso Boira, Luís Sabater, Julio Santoyo Santoyo, José Manuel Ramia, Fulthon Vela, Gloria Palomares, Miguel Ángel Suárez, Sandra Ruíz, Francisco Espín, Luis Iglesias Díez, Belén Martín, Míriam Alkorta, Berta Tió, Esteban Cugat, María Isabel García-Domingo, J. García i Castell, Núria Peláez, Benito González Conde, Luís Secanella, Alberto Carabias, Mireia Galofré, David Romero Pacheco, Alejandro Pérez, Cristina Ballester, Ana Belén Vico, Manuel Richard González, M.J. Paloma, Rafael López‐Andújar, I Hervás, Lorena Solar, Celia Villodres-Tudela, Enrique Artiguez
article en
1 citations

Abstract

The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This uncertainty raises the question of whether LP presents different morbidity and mortality profiles depending on the neoplasm type, potentially aiding decision-making. To compare postoperative outcomes by tumor type in a prospective series of LPs in Spain. The SPANDISPAN Project is a prospective, multicenter, observational study conducted in hepato-pancreato-biliary units from February 2022 to January 2023. A total of 311 patients from 41 Spanish centers participated. Patients were categorized by etiology: Adenocarcinoma (ADC), Intraductal Papillary Mucinous + Mucinous Cystic Neoplasms (IPMN + MCN), Neuroendocrine Tumors (NET), and Others. Pancreatic surgery-specific complications were defined by the International Study Group on Pancreatic Surgery (ISGPS). Postoperative complications were similar overall and for Clavien-Dindo grade > II. No significant differences were observed in POPF, except that grade B/C was more frequent in NET (29.6 %, p < 0.039), mainly due to grade B (53.3 %). No differences were found in PPH or DGE, though the severity of hemorrhage differed significantly (p < 0.035), with grade B more common in Others and grade C in NET (66.7 %). No significant differences in complication rates were found based on etiology. Non-functioning NETs in elderly patients should be carefully assessed due to the increased severity of POPF, PPH, and reoperation rates.

Asian Journal of SurgeryVol. 48(7)
Universitat de Miguel Hernández d'Elx (ES), Bellvitge University Hospital (ES), Marqués de Valdecilla University Hospital (ES), Hospital Regional Universitario de Málaga (ES), Instituto de Investigación Biosanitaria de Granada (ES), Hospital Universitario Virgen de las Nieves (ES), Clinica Universidad de Navarra (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Donostiako Unibertsitate Ospitalea (ES), Hospital General de Elda (ES), Hospital Universitario Virgen del Rocío (ES), INCLIVA Health Research Institute (ES)
Universidad de Málaga, Universitat de València, INCLIVA Instituto de Investigación Sanitaria, Instituto de Salud Carlos III
Good health and well-being
Openalex Percentile: Top 22%
Pancreatic and Hepatic Oncology Research
1.05
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.