Pharmacokinetic and pharmacodynamic evaluation of sulbactam‐durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem‐resistant <i>Acinetobacter baumannii‐calcoaceticus</i> complex
Sulbactam-durlobactam monotherapy dosed at 2 g every 4 h (3-h infusion) in CVVH achieved PD targets for this CRAB isolate with a MIC of 4/4 mcg/ml. Although sulbactam-durlobactam monotherapy resulted in initial microbiological clearance for the CRAB bacteremia, recurrence occurred, and the patient ultimately died.
Authors
- Ellen G Kline (ORCID: https://orcid.org/0009-0006-7167-6368)
- Aliaa Fouad (ORCID: https://orcid.org/0009-0007-6467-1806)
- Wesley D. Kufel (ORCID: https://orcid.org/0000-0001-7703-096X)
- Nabil Zeineddine
- Hanna F. Roenfanz (ORCID: https://orcid.org/0000-0002-0990-0932)
- Kathleen J. Hanrahan
- Ryan K. Shields (ORCID: https://orcid.org/0000-0001-9794-5665)
- Joseph L. Kuti (ORCID: https://orcid.org/0000-0002-4464-3126)
- John F. Warner
Institutions
- Binghamton University (US)
- Hartford Hospital (US)
- State University of New York (US)
- University of Pittsburgh (US)
- SUNY Upstate Medical University (US)
- Upstate University Hospital (US)
- Arnot Ogden Medical Center (US)
- Hartford Financial Services (United States)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1002/phar.70027
- Citations
- 7
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 4.14