Association of <i>OAS1</i> rs1051042 polymorphism with genetic susceptibility and clinical phenotypes to systemic lupus erythematosus in a Chinese population

Summary Polymorphism of OAS1 rs1051042 is associated with the genetic susceptibility and clinical phenotypes of Systemic Lupus Erythematosus (SLE) in the Chinese population. The genotype CG/GG and allele G of SNP rs1051042 in OAS1 are associated with increased genetic susceptibility of SLE. OAS1 rs1051042 polymorphism is associated with specific clinical phenotypes of SLE including malar rash, lupus nephritis, and anti‐dsDNA antibodies. The expression levels of OAS1 are more significantly increased in genotype GG than in genotype CC and CG of SNP rs1051042.