The PKC/NOX/ROS and PYK2/MEK/ERK/PARP signalling pathways drive TRPM2 channel activation induced by non-cytolytic oxidative stress in microglial cells
Our results support that PKC/NOX-mediated ROS generation and TRPM2-mediated Ca<sup>2+</sup>-induced activation of the PYK2/MEK/ERK pathway form a positive feedback mechanism to drive TRPM2 channel activation by non-cytolytic oxidative stress.
Authors
- Sharifah Alawieyah Syed Mortadza (ORCID: https://orcid.org/0000-0003-2110-2914)
- Lin‐Hua Jiang (ORCID: https://orcid.org/0000-0001-6398-0411)
- Nastaran Zahir (ORCID: https://orcid.org/0000-0002-7332-0705)
- Chengcheng Wei (ORCID: https://orcid.org/0000-0002-6634-0572)
Institutions
- Universiti Putra Malaysia (MY)
- University of Leeds (GB)
Publication Details
- Journal
- Redox Report
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1080/13510002.2025.2503131
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Alzheimer’s Research UK
- Xinxiang Medical University