Advancing Sensory Modulation Wound Healing of Bionic Polymer Microneedle Patch

ABSTRACT Diabetic wounds afflict diabetic patients due to their difficulty in healing and high recurrence rate. The complex etiology and pathogenesis of chronic wounds, current treatments have limitations in terms of suitability and efficacy, making it difficult to achieve the desired therapeutic outcome at all stages of the disease, leading to a high rate of recurrence. Significant progress has been made in the field of drug delivery. Microneedle (MN) based transdermal drug delivery systems have emerged as new solutions in the field of drug delivery. Zhao's group developed a polymer indwelling MN through a combined manufacturing strategy involving formwork replication and 3D transfer printing. With bionic adaptability and therapeutic exosome encapsulation, Benefiting from the Hofmeister effect, the mechanical strength of the PVA hydrogel exhibits ion responsiveness, and the resulting needle tip stiffness matches the varying tissue strengths strongly to ensure skin penetration and is softened by nitrate ions to accommodate the surrounding tissue after tip‐base separation and release of exosomes. Furthermore, due to the envelope of MSC‐derived exosomes, indwelling MN tips effectively promote the function of fibroblasts, endothelial cells of the vasculature, and macrophages to improve the wound microenvironment to accelerate wound repair for diabetic wound healing.