Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis
This study represents a comprehensive analysis of the CSF proteome across sporadic and genetic causes of ALS that resolves differences among these ALS subgroups and also identifies proteins that distinguish symptomatic from asymptomatic gene carriers. These new data point to varying pathogenic pathways that result in an otherwise clinically indistinguishable disease.
Authors
- Mark A. Garret (ORCID: https://orcid.org/0000-0002-3350-338X)
- Cindy V. Ly (ORCID: https://orcid.org/0000-0002-7063-5170)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Caroline M Watson (ORCID: https://orcid.org/0000-0001-6574-0833)
- Christina Fournier (ORCID: https://orcid.org/0000-0002-1561-2419)
- James D. Berry (ORCID: https://orcid.org/0000-0003-0898-6081)
- Nicola Ticozzi (ORCID: https://orcid.org/0000-0001-5963-7426)
- Jonathan S. Mill (ORCID: https://orcid.org/0000-0003-1115-3224)
- Eric B. Dammer (ORCID: https://orcid.org/0000-0003-2947-7606)
- Duc Minh Duong (ORCID: https://orcid.org/0000-0001-5880-1888)
- Zachary T. McEachin (ORCID: https://orcid.org/0000-0002-2369-8726)
- Federico Verde (ORCID: https://orcid.org/0000-0002-3977-6995)
- Eleanor V. Thomas (ORCID: https://orcid.org/0000-0003-2227-884X)
- Anantharaman Shantaraman (ORCID: https://orcid.org/0000-0003-1384-941X)
- Alberto Doretti (ORCID: https://orcid.org/0000-0002-1015-7365)
- Lingyan Ping (ORCID: https://orcid.org/0000-0002-2623-5145)
- Adam N. Trautwig
- Fang Wu (ORCID: https://orcid.org/0000-0003-3189-6148)
- Edward J. Fox
- Qi Guo (ORCID: https://orcid.org/0000-0003-2244-2101)
- James J. Lah (ORCID: https://orcid.org/0000-0002-8810-620X)
- Antonia Ratti
- Nicholas T. Seyfried
- Jonathan Glass
Institutions
- Emory University (US)
- University of Milan (IT)
- Washington University in St. Louis (US)
- Massachusetts General Hospital (US)
- IRCCS Istituto Auxologico Italiano (IT)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13024-025-00838-9
- Citations
- 4
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Muscular Dystrophy Association
- Ministero della Salute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke