Five new phenolics from the red resin of <i>Dracaena cochinchinensis</i>

Five undescribed phenolics including three new flavonoids (<b>1</b>-<b>3</b>), one new flavone glycoside (<b>4</b>) and one neolignan (<b>5</b>), together with seven known compounds were isolated from the resins of <i>Dracaena cochinchinensis</i> (Chinese dragon's blood). Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and electronic circular dichroism (ECD) data analysis. In addition, biological evaluation of compounds <b>1</b>-<b>5</b> on anti-renal fibrotic activities were conducted, and the results showed that compounds <b>1a</b>, <b>2</b>, and <b>5</b> display anti-renal fibrotic activities in TFG-<i>β</i> induced NRK-52e cells.

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Publication Details

Journal
Journal of Asian Natural Products Research
Published
2025-05-15
DOI
https://doi.org/10.1080/10286020.2025.2497279
Primary Topic
Phytochemical Studies and Bioactivities
Type
article
Field-Weighted Citation Impact
0.00

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article

Five new phenolics from the red resin of Dracaena cochinchinensis

Hong Shi, Nan Lin, Yong‐Xian Cheng
Journal of Asian Natural Products Research
Phytochemical Studies and Bioactivities
article

Five new phenolics from the red resin of Dracaena cochinchinensis

Hong Shi, Nan Lin, Yong‐Xian Cheng
article en

Abstract

Five undescribed phenolics including three new flavonoids (<b>1</b>-<b>3</b>), one new flavone glycoside (<b>4</b>) and one neolignan (<b>5</b>), together with seven known compounds were isolated from the resins of <i>Dracaena cochinchinensis</i> (Chinese dragon's blood). Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and electronic circular dichroism (ECD) data analysis. In addition, biological evaluation of compounds <b>1</b>-<b>5</b> on anti-renal fibrotic activities were conducted, and the results showed that compounds <b>1a</b>, <b>2</b>, and <b>5</b> display anti-renal fibrotic activities in TFG-<i>β</i> induced NRK-52e cells.

Journal of Asian Natural Products ResearchVol. 27(7)
Shenzhen University (CN), Chengdu University of Traditional Chinese Medicine (CN)
National Science Fund for Distinguished Young Scholars
Openalex Percentile: Top 90%
Phytochemical Studies and Bioactivities
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