Longitudinal proteomic analysis of pathophysiology in plasma and bronchoalveolar lavage fluid of patients with ARDS
The proteomics of plasma and BALF from patients with ARDS were compared in both the acute and subacute phases. In BALF in the acute phase, humoral immunity, mainly B-cell receptor signaling, was activated, whereas the HSP90 cycle and protein folding mechanisms were inactivated.
Authors
- Fuminori Sugihara (ORCID: https://orcid.org/0000-0002-6228-4593)
- Jun Oda (ORCID: https://orcid.org/0000-0002-8254-3716)
- Yumi Mitsuyama (ORCID: https://orcid.org/0000-0002-6272-6910)
- Hiroshi Ogura (ORCID: https://orcid.org/0000-0002-5013-2445)
- Hisatake Matsumoto (ORCID: https://orcid.org/0000-0001-5771-570X)
- Satoshi Fujimi
Institutions
- Osaka Prefectural Medical Center (JP)
- Osaka City General Hospital (JP)
- Kobe University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Intensive Care
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s40560-025-00793-z
- Citations
- 4
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Chugai Pharmaceutical
- Japan Society for the Promotion of Science