A One-Pot Synthesis of Substituted Pyrrolo[2,1-<i>a</i>]isoquinolines via an Oxidation/Annulation Sequence of 2-(3,4-Dihydroisoquinolin-2(1<i>H</i>)-yl)malononitriles
A highly effective oxidation/annulation reaction between 2-isocyanoacetates and 2-(3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)malononitriles has been successfully developed to give substituted pyrrolo[2,1-<i>a</i>]isoquinoline derivatives with moderate to good yields in a one-pot manner.
Authors
- Shao‐Hua Wang (ORCID: https://orcid.org/0000-0002-4347-8245)
- Feng Qiu (ORCID: https://orcid.org/0000-0001-5505-8670)
- Wen Bao (ORCID: https://orcid.org/0000-0003-2295-3905)
- K.‐C. HOU (ORCID: https://orcid.org/0009-0007-3466-8577)
- Bang‐Hong Zhang
- Ye Zhang (ORCID: https://orcid.org/0000-0001-7433-1820)
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
- Runze Li (ORCID: https://orcid.org/0000-0002-6642-5904)
- Dao‐Yong Zhu (ORCID: https://orcid.org/0000-0001-7094-8700)
- Zi-Qin Wei
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1021/acs.joc.5c00639
- Citations
- 2
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Lanzhou Science and Technology Bureau
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Science and Technology Program of Gansu Province