ANTI-MOTION SICKNESS EFFECT OF NEW HETEROCYCLIC COMPOUNDS LKHT 1-22 AND LKHT 4-22
Experiments with rats showed that new heterocyclic compounds – derivatives of nicotinic acid LKhT 1-22 and LKhT 4-22 at a dose of 50 mg/kg – had a pronounced anti-motion sickness effect, as they increased food intake by animals following rotation in 1.8 and 2.1 times, respectively. The vestibuloprotective effect of these compounds excelled that of mexicor (ethylmethylhydroxypyridine succinate) in 1.3 and 1.5 times, respectively.
Authors
- Vik.V. Yasnetsov
- V. V. Yasnetsov (ORCID: https://orcid.org/0000-0002-6399-3703)
- Yu. V. Ivanov (ORCID: https://orcid.org/0000-0003-2105-254X)
- S.R. Karsanova
Publication Details
- Journal
- Aerospace and Environmental Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.21687/0233-528x-2025-59-2-61-64
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00