Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth
Enhanced GLUT1 expression and oncogenic insulin signaling drive elevated glucose uptake in HNSCC, which contribute to the maintenance of redox homeostasis and tumor growth. Disrupting both glucose uptake and redox balance may offer a promising therapeutic approach.
Authors
- Tae Gyu Oh (ORCID: https://orcid.org/0000-0002-2756-3546)
- Joshua H. Choe (ORCID: https://orcid.org/0000-0001-7094-3766)
- Shin Yup Lee (ORCID: https://orcid.org/0000-0002-2121-7335)
- Bok‐Soon Lee (ORCID: https://orcid.org/0000-0002-0896-2883)
- Junho K. Hur (ORCID: https://orcid.org/0000-0003-3794-1149)
- Hoon Hur (ORCID: https://orcid.org/0000-0002-5435-5363)
- Jung‐whan Kim (ORCID: https://orcid.org/0000-0002-7829-1480)
- Joselyn Padilla (ORCID: https://orcid.org/0000-0002-1898-1041)
- Dinesh Thotala (ORCID: https://orcid.org/0000-0001-5355-6406)
- Yea–In Park (ORCID: https://orcid.org/0000-0002-7851-8470)
- Pankaj K. Singh (ORCID: https://orcid.org/0000-0001-8903-0131)
- Ji Yun Jeong (ORCID: https://orcid.org/0000-0001-6167-4998)
- Simbarashe Mazambani (ORCID: https://orcid.org/0000-0002-6554-7889)
- Tae Hoon Kim (ORCID: https://orcid.org/0000-0003-3950-7557)
- Jiyoung Lee (ORCID: https://orcid.org/0000-0001-8503-4805)
- Chul‐Ho Kim (ORCID: https://orcid.org/0000-0002-2161-4488)
- An H. Nguyen
- Seong-Ho Park
Institutions
- Boston Medical Center (US)
- Harvard University (US)
- Medical University of South Carolina (US)
- The University of Texas at Dallas (US)
- George Washington University (US)
- Harvard University Press (US)
- Kyungpook National University (KR)
- Dana-Farber Cancer Institute (US)
- Oklahoma State University Oklahoma City (US)
- Hanyang University (KR)
- University of Oklahoma Health Sciences Center (US)
- Ajou University (KR)
- University of Oklahoma (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1158/2767-9764.crc-23-0506
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94