Photoinduced Cobalt-Catalyzed Carbonyl Umpolung Alkenylation
Herein we introduce a cobalt-catalyzed umpolung strategy for radical carbonyl alkenylation. This method provides an alternative pathway for producing Grignard-type products from (hetero)aryl vinyl bromides and aliphatic aldehydes without pre-functionalization. The method is distinguished by its broad substrate scope, mild reaction conditions, and simple catalytic system. Upon specific activation of the carbonyl group with AcI, a cobaloxime complex catalyst facilitates the selective reduction of the resulting α-oxy iodide through an atom transfer process.
Authors
- Ban‐Feng Ruan (ORCID: https://orcid.org/0000-0001-7913-7824)
- Fei Pan (ORCID: https://orcid.org/0000-0002-9015-3013)
- Shi‐Kai Xiang (ORCID: https://orcid.org/0000-0002-7293-8546)
- Bi‐Qin Wang
- Yi Zhao (ORCID: https://orcid.org/0000-0003-2555-2154)
- Yuhang Fan (ORCID: https://orcid.org/0000-0001-9645-0548)
- Hao Cheng (ORCID: https://orcid.org/0000-0003-4357-5640)
Institutions
- Sichuan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1021/acs.orglett.5c01364
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province