Quantification of bactericidal activity using the PATHFAST TB LAM Ag assay during the first 14 days of pulmonary tuberculosis treatment
Our findings suggest that the PATHFAST-LAM can quantify bactericidal activity in the first 14 days of treatment with a quick turnaround time. The test's utility to monitor conversion from positive to negative and to predict relapse-free cure compared to culture-based methods should be determined in longer trials.
Authors
- Yongge Liu (ORCID: https://orcid.org/0000-0002-3982-4176)
- Ayumi Akinaga (ORCID: https://orcid.org/0009-0002-2569-2827)
- Andreas H. Diacon (ORCID: https://orcid.org/0000-0001-8641-6792)
- Masanori Kawasaki (ORCID: https://orcid.org/0000-0003-1377-6273)
- Remous Ocloo (ORCID: https://orcid.org/0000-0002-7368-8745)
- Atsushi Yanagida
- Naofumi Yoda
Institutions
- Otsuka (Japan) (JP)
- Task Applied Science (ZA)
- GC Corporation (Japan) (JP)
- Otsuka Pharmaceutical (Spain) (ES)
Publication Details
- Journal
- Frontiers in Antibiotics
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/frabi.2025.1574688
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58