Propranolol is efficacious against <i>Aspergillus</i> and <i>Fusarium</i> corneal isolates <i>in vitro</i> and in a murine model of <i>Aspergillus</i> keratitis

Fungal keratitis is a severe corneal infection most commonly caused by filamentous fungi. Even with prompt treatment with current antifungals, it often results in corneal perforation and blindness. In this report, we observe that the beta-adrenergic antagonist, propranolol, displays antifungal activity against <i>Aspergillus</i> and <i>Fusarium</i> corneal isolates <i>in vitr</i>o and strikingly blocks disease establishment in a murine model of <i>Aspergillus fumigatus</i> keratitis. These findings suggest that beta-blockers have potential as a novel FK treatment.<b>CLINICAL TRIALS</b>This study is registered with ClinicalTrials.gov as NCT00997035 (MUTT Trial).

Authors

Institutions

Publication Details

Journal
Antimicrobial Agents and Chemotherapy
Published
2025-05-15
DOI
https://doi.org/10.1128/aac.01664-24
Primary Topic
Ocular Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis

Kevin K. Fuller, Jorge D. Lightfoot, Jane T. Jones, Brandon S. Ross et al.
Antimicrobial Agents and Chemotherapy
Ocular Infections and Treatments
article

Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis

Kevin K. Fuller, Jorge D. Lightfoot, Jane T. Jones, Brandon S. Ross, Emily M. Adams, Ruina Bao, Manali M. Kamath, Robert A. Cramer, Cecilia Gutierrez-Perez, Namperumalsamy Venkatesh Prajna, Chetan K. Pavuluri, Galini Poimenidou, Michael E. Zegans
article en

Abstract

Fungal keratitis is a severe corneal infection most commonly caused by filamentous fungi. Even with prompt treatment with current antifungals, it often results in corneal perforation and blindness. In this report, we observe that the beta-adrenergic antagonist, propranolol, displays antifungal activity against <i>Aspergillus</i> and <i>Fusarium</i> corneal isolates <i>in vitr</i>o and strikingly blocks disease establishment in a murine model of <i>Aspergillus fumigatus</i> keratitis. These findings suggest that beta-blockers have potential as a novel FK treatment.<b>CLINICAL TRIALS</b>This study is registered with ClinicalTrials.gov as NCT00997035 (MUTT Trial).

Antimicrobial Agents and ChemotherapyVol. 69(6)
Dartmouth College (US), Dartmouth–Hitchcock Medical Center (US), Lawrence University (US), University of Pittsburgh (US), Aravind Eye Hospital (IN), University of Oklahoma Health Sciences Center (US)
Cystic Fibrosis Foundation, Research to Prevent Blindness, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of Allergy and Infectious Diseases
Good health and well-being
Openalex Percentile: Top 83%
Ocular Infections and Treatments
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.