Chondrocyte lysates activate NLRP3 inflammasome-induced pyroptosis in synovial fibroblasts to exacerbate knee synovitis by downregulating caveolin-1
CLs were endocytosed by FLSs through CAV1, and the CL-specific protein LPP stimulated NLRP3 inflammasome-mediated pyroptosis and synovitis by inhibiting CAV1 expression. Our findings offer a novel therapeutic target for treating synovitis.
Authors
- Chengyun Zhang
- Zongrui Jiang (ORCID: https://orcid.org/0000-0001-8259-4540)
- Zhijian Yang (ORCID: https://orcid.org/0000-0003-4175-2631)
- Shu Hu (ORCID: https://orcid.org/0000-0002-5183-5791)
- Ruonan Liu (ORCID: https://orcid.org/0000-0001-9181-6934)
- Zhi‐Qi Zhang (ORCID: https://orcid.org/0000-0001-5909-0408)
- Xue Du (ORCID: https://orcid.org/0000-0003-4604-7157)
Institutions
- Sun Yat-sen University (CN)
- Second Hospital of Shandong University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Second Affiliated Hospital of Shandong University of TCM (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13075-025-03573-0
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Shandong Province