Depression, antidepressant use, and breast cancer incidence in the Sister Study cohort
Depression was not associated with breast cancer risk. We observed a suggestion of a reduction in risk associated with antidepressant use. The analysis evaluating the association by specific drug types, showed a suggestion of a reduction in breast cancer risk associated with use of SSRIs. The negative association with overall antidepressant use and SSRIs, was stronger in those with BMI < 25, which could reflect a dose effect. This was the first study to examine the association between depression, antidepressant use, and breast cancer risk in a large genetic-risk-enriched cohort.
Authors
- Molly Rogers (ORCID: https://orcid.org/0009-0004-0437-8016)
- Aimee A. D’Aloisio
- Deborah B. Bookwalter
- Mary V. Díaz-Santana (ORCID: https://orcid.org/0000-0002-3580-6405)
- Hazel B. Nichols (ORCID: https://orcid.org/0000-0003-0972-1560)
- Katie M. O’Brien (ORCID: https://orcid.org/0000-0002-1931-1349)
- Dale P. Sandler (ORCID: https://orcid.org/0000-0002-6776-0018)
- Jihye Park (ORCID: https://orcid.org/0000-0002-5082-4759)
- Clarice Ring Weinberg (ORCID: https://orcid.org/0000-0002-7713-8556)
Institutions
- University of North Carolina at Chapel Hill (US)
- United States Nuclear Regulatory Commission (US)
- Westat (United States) (US)
- National Institute of Environmental Health Sciences (US)
- Social and Scientific Systems (United States) (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13058-025-02043-4
- Citations
- 2
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Institute of Environmental Health Sciences