Difluorocarbene/H<sub>2</sub>O Serving as a CO<sub>2</sub> Equivalent for Insertion into Oxiranes
A difluorocarbene-enabled regioselective C(sp<sup>3</sup>)-O bond cleavage of oxiranes has been developed. The protocol provides an efficient and practical approach to cyclic carbonates under mild conditions. Significantly, the generation of difluorocarbene with BrCF<sub>2</sub>CO<sub>2</sub>Et/H<sub>2</sub>O serving as a CO<sub>2</sub> equivalent under metal-free conditions has been disclosed.
Authors
- Bingchuan Yang (ORCID: https://orcid.org/0000-0003-1195-5833)
- Huayan Xu (ORCID: https://orcid.org/0000-0003-0801-0695)
- Shuo Tang (ORCID: https://orcid.org/0000-0003-2470-6756)
- Dandan Zuo
- Yafei Li (ORCID: https://orcid.org/0000-0002-6136-863X)
- Pan Li (ORCID: https://orcid.org/0000-0001-6658-9207)
- Jingjing Zhao
- Mengna Hua
- Chuanyang Song
Institutions
- Henan University (CN)
- Qilu Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1021/acs.orglett.5c01473
- Citations
- 4
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.16
Funders
- National Natural Science Foundation of China