Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Dormancy-prone breast cancer cells depend on the class III PI3K to mediate peripheral lysosomal positioning and mTORC1 hyperactivity, which can be targeted to blunt breast cancer metastasis.
Authors
- Julio A. Aguirre‐Ghiso (ORCID: https://orcid.org/0000-0002-6694-6507)
- Virginie Calderon (ORCID: https://orcid.org/0000-0002-4267-3452)
- Graham MacLeod (ORCID: https://orcid.org/0000-0001-6401-9307)
- Jean‐François Côté (ORCID: https://orcid.org/0000-0001-7055-2642)
- Claudia L. Kleinman (ORCID: https://orcid.org/0000-0002-5158-7126)
- Stéphane Angers (ORCID: https://orcid.org/0000-0001-7241-9044)
- James V. Alvarez (ORCID: https://orcid.org/0000-0003-2910-7621)
- Hellen Kuasne (ORCID: https://orcid.org/0009-0000-1256-790X)
- Alain Pacis (ORCID: https://orcid.org/0000-0003-4883-6176)
- Islam E. Elkholi (ORCID: https://orcid.org/0000-0002-8019-2481)
- Steven Hébert (ORCID: https://orcid.org/0000-0001-6267-8595)
- Camille Malouf (ORCID: https://orcid.org/0000-0002-1066-8376)
- Ana P. Gomes (ORCID: https://orcid.org/0000-0003-0881-727X)
- Morag Park (ORCID: https://orcid.org/0000-0001-5400-606X)
- Jia Wu (ORCID: https://orcid.org/0009-0002-0584-896X)
- Amélie Robert (ORCID: https://orcid.org/0000-0002-7235-0881)
- Stanislav Drápela (ORCID: https://orcid.org/0000-0002-9421-9972)
Institutions
- Albert Einstein College of Medicine (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Toronto (CA)
- Jewish General Hospital (CA)
- Moffitt Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Occupational Cancer Research Centre (CA)
- McGill Genome Centre (CA)
- Montreal Clinical Research Institute (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1158/0008-5472.can-23-2654
- Citations
- 3
- Primary Topic
- Plant tissue culture and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- U.S. Department of Defense
- American Cancer Society
- Samuel Waxman Cancer Research Foundation
- Melanoma Research Alliance
- Cancer Research Society
- Compute Canada
- Fondation du cancer du sein du Québec
- Canadian Cancer Society
- Canada Research Chairs
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- National Cancer Institute