Histological and Histomorphometric Evaluation of RegenerOss®: A Porcine-Derived Bone Substitute for Guided Bone Regeneration

Tissue regeneration remains a key challenge in modern dentistry, particularly in cases of bone loss that hinder implant placement. This study evaluates the regenerative potential of RegenerOss®, a porcine-derived bone substitute, through histological and histomorphometric analysis in patients with alveolar bone defects. Twelve patients underwent guided bone regeneration using RegenerOss®, followed by histological evaluation of newly formed bone (NFB) and residual biomaterial. The results indicate that RegenerOss® effectively promotes bone formation, with an average NFB percentage of 34% and a low residual biomaterial percentage (6%). Osteoclast-mediated resorption was observed, confirming its role in physiological remodeling. Biocompatibility was high, with minimal inflammatory infiltrates in most cases. A scoring system (SCORE2) integrating qualitative and quantitative variables demonstrated a strong positive correlation with NFB, providing a reliable metric for bone regeneration quality. Regression analysis confirmed a linear relationship between SCORE2 and bone formation. The study highlights RegenerOss® as a promising biomaterial with excellent osteoconductive properties, predictable integration, and progressive resorption. However, variability among patients suggests that regeneration is influenced by local and systemic factors. Further studies are required to explore its full potential in different bone defect scenarios.