Electrophilic (Hetero)Arene C–H Nitration by Ferric Nitrate Nonahydrate in Hexafluoroisopropanol
In this article, we provide an extended substrate scope and more detailed mechanistic studies of an operationally simple and generally applicable arene nitration that we previously reported. This method utilizes safe and inexpensive Fe(NO<sub>3</sub>)<sub>3</sub>•9H<sub>2</sub>O as the nitro source in easily recyclable HFIP and obviates the need for corrosive acids (HNO<sub>3</sub> + H<sub>2</sub>SO<sub>4</sub>). As a result, we speculated that it could serve as an effective substitute for the traditional mixed acid approach under most scenarios due to its operational simplicity. A general guidance for the application of this method was provided.
Authors
- Yuzhu Zheng
- Youwei Xie (ORCID: https://orcid.org/0000-0003-3831-4059)
- Ying Zhu (ORCID: https://orcid.org/0000-0002-8689-0897)
- Zongyi Liu (ORCID: https://orcid.org/0009-0007-3763-3484)
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1021/acs.joc.5c00137
- Citations
- 4
- Primary Topic
- Chemical Synthesis and Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China