Atf3 + senescent chondrocytes mediate meniscus degeneration in aging
We identified Atf3 + senescent chondrocytes as a key pathogenic population in the aging meniscus, driving degeneration via the ANGPTL4 pathway. Targeting Atf3 + cells or ANGPTL4 signaling may offer new therapeutic strategies for age-related meniscus degeneration and arthritis.
Authors
- Zhangyi Pan
- Lei Lü (ORCID: https://orcid.org/0000-0001-9139-8955)
- A. Fan (ORCID: https://orcid.org/0000-0003-4822-0582)
- Jingyi Wang (ORCID: https://orcid.org/0000-0002-0423-6868)
- Xiao Wang (ORCID: https://orcid.org/0009-0003-1613-7343)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-3538-9349)
- Yaohui Liu (ORCID: https://orcid.org/0000-0002-0973-097X)
- Min Ma (ORCID: https://orcid.org/0000-0003-3602-6846)
- Feng Yin (ORCID: https://orcid.org/0000-0003-2667-1921)
- Kun Tao (ORCID: https://orcid.org/0000-0003-1422-9482)
Institutions
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13075-025-03566-z
- Citations
- 2
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Ministry of Science and Technology of the People's Republic of China