Leveraging Interoperable Electronic Health Record (EHR) Data for Distributed Analyses in Clinical Research: Technical Implementation Report of the HELP Study

The HELP study highlights challenges and opportunities in leveraging EHR data for clinical research, particularly in the absence of mandatory data standards and resource-intensive data harmonization efforts. Despite limitations in data availability and quality, progress in digitization and interoperability frameworks offers hope for future improvements. Lessons learned from this study can inform the development of standardized methodologies and infrastructures for sustainable EHR data integration in research.