Isolation and characterization of a new diketopiperazine from <i>Cephalotrichum</i> sp. RD-ZLM03 isolated in Jinlun cave
A new diketopiperazine, spirotryprostatin C (<b>1</b>), as well as nine known compounds (<b>2</b>-<b>10</b>), were isolated from the fermentation broth of the karst cave derived fungus <i>Cephalotrichum</i> sp. RD-ZLM03. Their structures were determined based on spectroscopic and X-ray diffraction analysis. Compounds <b>2</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>8</b>, <b>9</b>, and <b>10</b> showed significant proangiogenic activities at the concentration of 25 μM in the zebrafish model.
Authors
- Ting Shu (ORCID: https://orcid.org/0000-0003-3050-2485)
- Li-Man Zhou
- Peihai Li (ORCID: https://orcid.org/0000-0002-4215-8485)
- Fan‐Dong Kong
- Hao Yi (ORCID: https://orcid.org/0000-0002-3682-5683)
- Pei Wang (ORCID: https://orcid.org/0000-0002-0221-7858)
- Caixia Wei (ORCID: https://orcid.org/0000-0001-5369-944X)
- Rongxiang Wu
Institutions
- Minzu University of China (CN)
- Qilu University of Technology (CN)
- State Ethnic Affairs Commission (CN)
- Shandong Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1080/10286020.2025.2497284
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China