Neuroprotective effects of <i>Morus alba</i> ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model

<i>Morus alba</i> formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of <i>Morus alba</i> (EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.