Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of focal seizures
Almost all TEAEs occurred before T-PSC. Similar conclusions regarding the tolerability and safety of perampanel would have been reached if the T-PSC design had been used. This suggests that the T-PSC design may potentially benefit participants by allowing earlier change from an ineffective treatment to an alternate treatment, which could reduce the risk of serious consequences of ineffective treatment, such as hospitalization.
Authors
- Anna Patten (ORCID: https://orcid.org/0000-0002-1319-8680)
- Wesley T. Kerr (ORCID: https://orcid.org/0000-0002-5546-5951)
- Jacqueline A. French (ORCID: https://orcid.org/0000-0003-2242-8027)
- Leock Y. Ngo (ORCID: https://orcid.org/0000-0002-8184-1367)
- Jocelyn Y. Cheng (ORCID: https://orcid.org/0000-0001-5318-5668)
- Liang Zhu
- Lavanya Biju
Institutions
- University of Pittsburgh (US)
- Neurelis (United States) (US)
- Eisai (United Kingdom) (GB)
- Eisai (United States) (US)
- New York University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1111/epi.18460
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Epilepsy Society
- Epilepsy Foundation
- Pfizer
- American Brain Foundation
- American Academy of Neurology
- University of Pittsburgh
- Sunovion
- SK Life Science
- Eisai
- H. Lundbeck A/S
- Epilepsy Society
- Medical Center, University of Pittsburgh
- National Institute of Neurological Disorders and Stroke