Lipocalin-2-mediated ferroptosis as a target for protection against light-induced photoreceptor degeneration
LCN2 is a key regulator of light-induced ferroptosis in photoreceptors by modulating the JNK pathway. Therefore, LCN2 presents a new target for the treatment of retinal degeneration.
Authors
- Ruyi Zhai (ORCID: https://orcid.org/0000-0002-7906-6357)
- Jun Ma (ORCID: https://orcid.org/0000-0002-5510-6895)
- Gezhi Xu (ORCID: https://orcid.org/0000-0001-8546-950X)
- Wenyi Tang (ORCID: https://orcid.org/0000-0003-3938-9300)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shandong Eye Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s10020-025-01250-1
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- China Primary Health Care Foundation
- Shanghai Hospital Development Center