Neuroprotective furanones from a soil-derived fungus <i>Penicillium paxilli</i> ga254
Three furanone derivatives (<b>1</b>-<b>3</b>), including one new compound, penicifuranone A (<b>1</b>), and one new natural product (<b>2</b>), along with one known dihydropyranone (<b>4</b>) were isolated from the solid rice medium fermentation of <i>Penicillium paxilli</i> ga254. The structures of these compounds were elucidated using comprehensive NMR spectroscopic analysis. This study represents the first report of these furanone derivatives from this fungus. Additionally, the neuroprotective effects of these compounds against oxygen-glucose deprivation/reperfusion injury in pheochromocytoma-12 cells were investigated.
Authors
- Xiaoqian Wu (ORCID: https://orcid.org/0000-0002-4441-5772)
- Hongping Long (ORCID: https://orcid.org/0000-0001-8891-5851)
- Jing Li (ORCID: https://orcid.org/0000-0001-6553-3914)
- Wen‐Xuan Wang (ORCID: https://orcid.org/0000-0002-7391-2954)
- Siqian Zhou
- Yajing Wang (ORCID: https://orcid.org/0000-0001-9364-8532)
- Guang Li (ORCID: https://orcid.org/0000-0003-2993-7588)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Puyang Vocational and Technical College (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1080/10286020.2025.2501025
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Key Research and Development Program of Hunan Province of China