Neurological manifestations of rhino-orbito-cerebral mucormycosis

Mucormycosis is a severe fungal infection that develops in immunocompromised patients. Rhino-orbito-cerebral mucormycosis (ROCM) is the most common and dangerous clinical form of infection, characterized by infection of the nasal cavities, paranasal sinuses, cervical spaces, orbits and intracranial structures. Aim. To describe a series of clinical observations, including 8 patients with ROCM from 2019 to 2023, to identify the features of neurological manifestations of ROCM. Materials and methods. This article describes our own experience in the management of 8 patients with rhino-orbito-cerebral mucormycosis (ROCM). Neurological syndromes of cranial nerve damage, vascular and inflammatory lesions of the nervous system within the framework of this syndrome are described. Results. Neurological complications of RCM were present in all patients and included damage to cranial nerves (in all cases), thrombosis of the cavernous sinuses, strokes and damage to the membranes of the brain. The algorithm of diagnosis of ROCM is presented, the tactics of selection of drug therapy and surgical care in the rehabilitation of foci of mucormycosis are described. The catamnesis was traced in each described case.