No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients
Histopathological tissue initiates epileptogenicity in focal epilepsy. However, our findings suggest that the EZ is not strictly a histopathological entity but a hybrid of abnormal cells and normal-appearing cells. Thus, SEEG events are biomarkers of epileptogenicity and not histopathology. Resecting of electrophysiological biomarkers of epileptogenicity may be more important than resecting all histopathology.
Authors
- Jason Karamchandani (ORCID: https://orcid.org/0000-0002-3906-5616)
- Elisabeth Simard‐Tremblay
- Mariam Al-Rashid
- Jean Gotman (ORCID: https://orcid.org/0000-0002-9796-5946)
- Nicolás von Ellenrieder (ORCID: https://orcid.org/0000-0003-0845-347X)
- Kenneth Alexis Myers (ORCID: https://orcid.org/0000-0001-7831-4593)
- Roy Dudley (ORCID: https://orcid.org/0000-0003-4437-0823)
- Bradley Osterman
- Marie‐Christine Guiot
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Montreal Children's Hospital (CA)
- King Fahd Hospital of the University (SA)
- McGill University Health Centre (CA)
- McGill University (CA)
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1111/epi.18459
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- McGill University
- Canadian Institutes of Health Research