Fe-S cluster deficiency drives small colony variant formation in persistent infections
sufB is a novel genetic determinant of stable SCV formation through Fe-S cluster deficiency, driving metabolic shifts that enhance immune evasion and chronic infection. Our findings highlight antibiotic stewardship and suggest potential therapeutic strategies for managing persistent SCV-associated infections.
Authors
- Feng Jiang (ORCID: https://orcid.org/0000-0002-8953-6498)
- Guoxiu Xiang
- Wenlong Yang (ORCID: https://orcid.org/0000-0003-3139-2767)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-6571-945X)
- Zhiyi Ye (ORCID: https://orcid.org/0000-0003-0285-7502)
- Hao Shen (ORCID: https://orcid.org/0000-0002-8698-5079)
- William J. Huang (ORCID: https://orcid.org/0000-0001-9048-4990)
- Qian Liu (ORCID: https://orcid.org/0000-0002-8078-1075)
- Yanan Wang (ORCID: https://orcid.org/0000-0002-0327-0458)
- Ying Jian (ORCID: https://orcid.org/0000-0001-5185-2455)
- Min Li (ORCID: https://orcid.org/0000-0002-8571-2909)
- Tianchi Chen
- Lei He (ORCID: https://orcid.org/0000-0003-4679-5462)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1016/j.jare.2025.05.018
- Citations
- 2
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China